SWEETS-SYNDROME WITH MYELOFIBROSIS AND LEUKEMIA - PARTIAL-RESPONSE TOINTERFERON

Sweet's syndrome with malignancy or acute neutrophilic dermatosis (AND ) is an unusual cutaneous disorder seen most commonly in association w ith acute myelogenous leukemia. A large majority of patients with AND and malignancy have neoplasms of hematopoietic, plasma cell or lymphoi d nature. The patient reported here had myelofibrosis, chronic myeloge nous leukemia and Sweet's syndrome. The individual lesions responded t o intralesional interferon-alpha(2), which has not to our knowledge be en reported previously. This result, however, was not as great as the response of AND to intralesional steroid injections.