The clinical, pathologic, immunohistochemical, and electron microscopi
c characteristics of a pure intracranial gangliocytoma in a 6-year-old
spayed female dog are presented. The tumor is very rare in humans, an
d has not been previously reported in the dog. The most remarkable fea
ture of this tumor was that it was composed of a single neuronal cell
type without the presence of glial elements, as demonstrated by the ne
gative immunohistochemical reaction to glial fibrillary acidic protein
.