GIANT-CELL GLIOBLASTOMA IN THE FRONTAL-CORTEX OF A DOG

A dark gray mass 3 cm in diameter replacing the right frontal cortex w as found in the brain of a 5-year-old male Doberman Pinscher dog at ne cropsy. Microscopic studies revealed that the mass consisted of a prol iferation of pleomorphic tumor cells: large bizarre or plump eosinophi lic cells, multinucleated giant cells, and small lymphocytic cells. Th ese neoplastic cells at the margin of the necrotic area had a psuedopa lisade arrangement and tended to proliferate around blood vessels. Imm unohistochemically, the tumor cells reacted intensely with the antibod y for vimentin and moderately with those for S-100 and glial fibrillar y acidic protein. This canine tumor is placed in the category of gliob lastoma or undifferentiated astrocytoma, which is analogous to human g iant cell glioblastoma.