THE INCLUSION COMPOUND OF EMULSIFIED CETOSTEARYL ALCOHOL WITH BETA-CYCLODEXTRIN AND A COMPETITIVE REACTION WITH A HYDROCORTISONE BETA-CYCLODEXTRIN INCLUSION COMPOUND IN AN OIL-IN-WATER CREAM

beta-cyclodextrin can form a solid inclusion compound with emulsified cetostearyl alcohol (ECA) by coprecipitation. This was proved by diffe rential scanning calorimetry (DSC), X-ray diffractometry, IR spectrome try and the determination of the foaming ability according to the Germ an Pharmacopeia (DAB 10) for ECA in the coprecipitate. The DSC result shows that both ingredients, cetostearyl alcohol and cetostearyl sulfa te, are included in the beta-CD cavity. The coprecipitate is therefore a mixture of inclusion compounds. ECA as a constituent of Hydrophilic Ointment (DAB 10) can substitute up to 10% hydrocortisone in Aqueous Hydrophilic Ointment (DAB 10) containing 1% HC as beta-CD inclusion co mpound under the conditions of preparation.