In research on effects of message variables, it is generally necessary
to examine responses to actual messages that represent, embody, or in
stantiate the values of the variable of interest. Researchers have lat
ely become attentive to problems of confounding in the use of individu
al concrete messages to represent abstract theoretical contrasts, and
replicated treatment comparisons are increasingly common in communicat
ion research. How to treat the replications factor in the statistical
analysis remains controversial. Whether to treat replication factors a
s fixed or as random hinges on what is assumed about the relationship
between abstract treatment contrasts and their concrete material imple
mentations. We argue that reflection on this relationship justifies a
general policy of treating replications as random. Two circumstances i
n which fixed-effects analyses might seem attractive (the case of matc
hed-message designs and the case of experimental manipulations occurri
ng outside of messages) are considered, but it is concluded that these
situations also require random-effects analyses.