6-AMINO-6-DEOXYASCORBIC ACID INDUCES APOPTOSIS IN HUMAN TUMOR-CELLS

Authors
GRDISA M KRALJ M ECKERTMAKSIC M MAKSIC ZB PAVELIC K
Citation
M. Grdisa et al., 6-AMINO-6-DEOXYASCORBIC ACID INDUCES APOPTOSIS IN HUMAN TUMOR-CELLS, Journal of cancer research and clinical oncology, 121(2), 1995, pp. 98-102
Citations number
31
Categorie Soggetti
Oncology
Journal title
Journal of cancer research and clinical oncology → ACNP
ISSN journal
01715216
Volume
121
Issue
2
Year of publication
1995
Pages
98 - 102
Database
ISI
SICI code
0171-5216(1995)121:2<98:6AIAIH>2.0.ZU;2-R
Abstract
6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell gro wth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, d rastic morphological changes were found. Although image analysis did n ot show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.