SYNTHESIS AND STUDY OF NOVEL BIODEGRADABLE OLIGO(ESTER AMIDE)S BASED ON SEBACIC ACID, OCTADECANEDIOIC ACID, 1,6-HEXANEDIAMINE AND EPSILON-CAPROLACTONE .2.

Two series of novel oligo(ester amide)s based on sebacic acid/1,6-hexa nediamine/epsilon-caprolactone and octadecanedioic acid/1,6-hexanediam ine/epsilon-caprolactone were synthesized. The determination of the mo lecular weights with both gel permeation chromatography and H-1 nuclea r magnetic resonance (n.m.r.) showed that they vary from 1000 to 6000. Differential scanning calorimetry and thermogravimetric analysis were employed for determining glass transitions, melting points, heats of melting and decomposition temperatures of the oligo(ester amide)s. Fou rier-transform infra-red and H-1-C-13 n.m.r. spectra were taken to con firm the composition of the novel oligo(ester amide)s. The test of enz ymatic hydrolysis was employed to assess the potential biodegradabilit y of these oligomers.