THE SBASE PROTEIN DOMAIN LIBRARY, RELEASE-5.0 - A COLLECTION OF ANNOTATED PROTEIN-SEQUENCE SEGMENTS

SBASE 5.0 is the fifth release of SBASE, a collection of annotated pro tein domain sequences that represent various structural, functional, l igand-binding and topogenic segments of proteins, SBASE was designed t o facilitate the detection of functional homologies and can be searche d with standard database-search programs. The present release contains over 79863 entries provided with standardized names and is cross-refe renced to all major sequence databases and sequence pattern collection s. The information is assigned to individual domains rather than to en tire protein sequences, thus SBASE contains substantially more cross-r eferences and links than do the protein sequence databases. The entrie s are clustered into >16 000 groups in order to facilitate the detecti on of distant similarities. SBASE 5.0 is freely available by anonymous 'ftp' file transfer from <ftp.icgeb.trieste.it >. Automated searching of SBASE with BLAST can be carried out with the WWW-server <http://ww w.icgeb.trieste.it/sbase/ >. and with the electronic mail server <sbas e@icgeb.trieste.it > which now also provides a graphic representation of the homologies. A related WWW-server <http://www.abc.hu/blast.html > and e-mail server <domain@hubi.abc.hu > predicts SBASE domain homolo gies on the basis of SWISS-PROT searches.