IN-VITRO EFFECTS OF SULFADIAZINE AND ITS METABOLITES ALONE AND IN COMBINATION WITH PYRIMETHAMINE ON TOXOPLASMA-GONDII

Authors
SCHOONDERMARKVANDEVEN E VREE T MELCHERS W CAMPS W GALAMA J
Citation
E. Schoondermarkvandeven et al., IN-VITRO EFFECTS OF SULFADIAZINE AND ITS METABOLITES ALONE AND IN COMBINATION WITH PYRIMETHAMINE ON TOXOPLASMA-GONDII, Antimicrobial agents and chemotherapy, 39(3), 1995, pp. 763-765
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
3
Year of publication
1995
Pages
763 - 765
Database
ISI
SICI code
0066-4804(1995)39:3<763:IEOSAI>2.0.ZU;2-H
Abstract
Sulfadiazine and the metabolites N4-acetyl-sulfadiazine, 4-OH-sulfadia zine, 5 OH-sulfadiazine, 5-OH-glucuornide-sulfadiazine, and 5-OH-sulfa te-sulfadiazine were tested separately and in combination with pyrimet hamine for the inhibitory activity on Toxoplasma gondii growth in vitr o. Except for N4-acetyl-sulfadiazine, all sulfa compounds possessed an ti-Toxoplasma activity. The addition of 0.05 mu g of pyrimethamine per ml, a concentration which in itself is not inhibitory, potentiated th e microbial activity of sulfadiazine and its metabolites 100 fold.