EFFECT OF ANTIOXIDANTS ON ADRIAMYCIN-INDUCED MICROSOMAL LIPID-PEROXIDATION

Authors
HIDA H COUDRAY C CALOP J FAVIER A
Citation
H. Hida et al., EFFECT OF ANTIOXIDANTS ON ADRIAMYCIN-INDUCED MICROSOMAL LIPID-PEROXIDATION, Biological trace element research, 47(1-3), 1995, pp. 111-116
Citations number
13
Categorie Soggetti
Biology
Journal title
Biological trace element research → ACNP
ISSN journal
01634984
Volume
47
Issue
1-3
Year of publication
1995
Pages
111 - 116
Database
ISI
SICI code
0163-4984(1995)47:1-3<111:EOAOAM>2.0.ZU;2-A
Abstract
Adriamycin (25 mu M) stimulated NADPH-dependent microsomal lipid perox idation about fourfold over control values. The tested antioxidants, z inc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) i nhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Ot hers antioxidants, e.g., glutathione, catalase, and selenium, were fou nd to have no effects. Our in vitro studies suggest that adriamycin ef fect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.