R. Lidgard et Mw. Duncan, UTILITY OF MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHTMASS-SPECTROMETRY FOR THE ANALYSIS OF LOW-MOLECULAR-WEIGHT COMPOUNDS, Rapid communications in mass spectrometry, 9(2), 1995, pp. 128-132
A range of low molecular weight compounds (<800 Da) have been examined
by matrix-assisted laser desorption time-of-flight mass spectrometry
to demonstrate the general analytical utility of this technique. The c
ompound classes investigated included: carbohydrates, quaternary ammon
ium salts, sterols, nucleosides, purine and pyrimidine bases, amino ac
ids, catecholamines, opioids, antibiotics, prostaglandins and a range
of macrocyclic metal complexes of porphyrins and phthalocyanines. Many
of the compounds tested are of biochemical, geochemical, industrial a
nd/or therapeutic interest. Most organic analytes gave intense protona
ted molecules, but some were characterized by sodium adduct ions (i.e.
, [M + Na](+)). The metal-containing compounds formed radical-cation m
olecular ions. In all instances the ions detected could be assigned, a
nd excellent agreements between calculated and experimental mass value
s were obtained.