DETERMINATION OF ACECLOFENAC USING ADSORPTIVE STRIPPING VOLTAMMETRIC TECHNIQUES ON CONVENTIONAL AND SURFACTANT CHEMICALLY-MODIFIED CARBON-PASTE ELECTRODES

An electroanalytical method for determination of the anti-inflammatory agent aceclofenac at the ppb level using adsorptive stripping voltamm etric techniques on conventional and surfactant chemically modified el ectrodes is developed. In this electroanalytical study a process of ac eclofenac adsorption on carbon particles has been identified. In order to improve the aceclofenac determination, a chemical modification of the carbon paste was carried out employing several hydrophobic substan ces such as phospholipid and fatty acids, as well as several surfactan ts such as the non-ionic Triton X-100 and Triton X-405 and anionic sod ium dodecyl sulfate. The influence of parameters such as pH, preconcen tration time, carbon/Nujol ratio, surfactant/carbon ratio, potential s can rate, etc., on sensitivity of the method were widely studied. The proposed method was applied to the determination of the active compoun d in tablets.