SHORT-TERM ORAL TREATMENT OF CANINE BENIGN PROSTATIC HYPERTROPHY WITHCHLORMADINONE ACETATE

Ten beagle dogs (4-8 years of age) with benign prostatic hypertrophy w ere treated daily for 7 or 14 days by a daily oral administration of c hlormadinone acetate (CMA), an anti-androgenic preparation, at a dose of 0.5 or 2.0 mg/kg/day. The groups of dogs treated with CMA at a dose of 2.0 mg/kg showed a greater reduction of the prostatic volume durin g 7 or 14 days of treatment than the group treated with 0.5 mg/kg of C MA. At 56 and 84 days after the start of CMA treatment, prostate volum e was reduced to 63 and 79% of the pre administration volume, respecti vely. No marked decrease in plasma LH or testosterone was found after the CMA treatment. These results indicate that the therapeutic effects of 7-day oral treatment with CMA at 2.0 mg/kg/day in dogs with BPH la st for about three months or longer without side effects.