CONGENITAL RENAL GLOMERULAR FIBROSIS IN A CASE OF SWINE CHONDRODYSPLASIA

A dwarf male Large White neonate showing Various external abnormalitie s was diagnosed to be chondrodysplasia. Microscopy revealed massive ac cumulation of eosinophilic homogeneous substance in the renal glomerul i, mainly along the caillary walls. The homogeneous substance, mainly consisted of type-III collagen, was not found in the primitive glomeru li in the superficial cortex, and was most frequently and intensely de posited in the mature glomeruli in the deep cortex. Electron microscop ically, the deposits consisted of the collagen fibrils with various st ructural abnormalities. Glomerular fibrosis might be attributed to in situ production of type-III collagen by glomerular cells with differen tiation and maturation, most likely by the mesangial cells.