Objectives: The purpose of this study was to build an experimental set
-up to assess continuously the humidification, heating and resistance
properties of heat-moisture exchangers (HMEs) under clinical condition
s. Design: The experimental set-up consists of a patient model, measur
ement systems and a ventilator. Setting: Surgical ICU, University Hosp
ital of Rotterdam. Materials: A clinically used HME. Measurements and
results: The air flow, pressure in the ventilation circuit, pressure d
ifference over the HME, and partial water vapour pressure and temperat
ure at each side of the HME were measured. The resistance, absolute hu
midity, humidification efficiency and temperature difference at the pa
tient side of the HME were calculated. Measurements were performed dur
ing 24 h. The temperature output, humidity output and lung mechanics o
f the patient model were similar to values found in mechanically venti
lated patients. The measurement system was in agreement with the ISO d
raft standard and was capable of measuring dynamic variation of water
and heat exchange over the range of a clinically used ventilator setti
ng. Conclusion: The experimental setup described is reliable for evalu
ating HMEs and can also be used for future clinical evaluation of HMEs
. The main advantages of this set-up over those described previously a
re: (i) measurements of dynamic variations of water and heat exchange;
(ii) on-line measurements of expiratory, as well as inspiratory resis
tance.