LEFT ATRIAL SPONTANEOUS ECHO CONTRAST IN ASYMPTOMATIC PATIENTS WITH AMECHANICAL VALVE PROSTHESIS

Background. Valve thromboembolism may be a fatal complication of mecha nical valve prosthesis if detected late. Spontaneous echo contrast (SE C) is a well-documented prothrombotic phenomenon; here we report it in asymptomatic patients with a mechanical valve prosthesis. Methods. Ni nety-two asymptomatic patients with a mechanical valve prosthesis for underlying rheumatic heart disease underwent transesophageal echocardi ography. Appendage area, peak filling and emptying velocities of the l eft atrial appendage, and the presence or absence of SEC and thrombi w ere determined. The results of 56 patients without SEC or thrombi (gro up I) were compared with those of 24 patients with SEC and no thrombi (group II) and 12 patients with thrombi (group III). Results. Spontane ous echo contrast was present in 39% of the asymptomatic patients with a mechanical valve prosthesis. Although 12 patients had cardiac throm bi, including valve thrombi in 4, no patients presented symptoms. Anti coagulant therapy had no significant association with SEC and atrial t hrombi. There was a significantly greater prevalence of atrial fibrill ation and mitral prosthesis in groups II and III than in group I. Two patterns of left atrial appendage flow were identified: one was organi zed biphasic flow with peak filling velocities of 41.2 +/- 17.2 cm/s a nd emptying velocities of 40.5 +/- 17.5 cm/s. The other showed irregul ar, very low peak filling velocities (10.4 +/- 11.5 cm/s) and emptying velocities (12.3 +/- 13.1 cm/s). The former flow pattern was associat ed with sinus rhythm and the latter form was associated with atrial fi brillation. Conclusions. There was a relatively high prevalence of SEC and thrombi in patients with a mechanical valve prosthesis. Patients with a valve prosthesis may not have clinical symptoms. Anticoagulatio n intensity was not associated with the occurrence of SEC and thrombi. Patients with a mitral valve prosthesis and atrial fibrillation were identified as a high-risk of subgroup for the development of SEC and t hrombi.