HELIOFERINS - NOVEL ANTIFUNGAL LIPOPEPTIDES FROM MYCOGONE ROSEA - SCREENING, ISOLATION, STRUCTURES AND BIOLOGICAL PROPERTIES

Authors
GRAFE U IHN W RITZAU M SCHADE W STENGEL C SCHLEGEL B FLECK WF KUNKEL W HARTL A GUTSCHE W
Citation
U. Grafe et al., HELIOFERINS - NOVEL ANTIFUNGAL LIPOPEPTIDES FROM MYCOGONE ROSEA - SCREENING, ISOLATION, STRUCTURES AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 48(2), 1995, pp. 126-133
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
2
Year of publication
1995
Pages
126 - 133
Database
ISI
SICI code
0021-8820(1995)48:2<126:H-NALF>2.0.ZU;2-O
Abstract
Helioferins A and B were detected as novel aminolipopeptides in cultur es of Mycogone rosea DSM 8822 in the course of a screening for mediato rs of helianthate anion transfer from aqueous to toluene phases. Their structures as novel antibiotics and cytotoxic agents were elucidated by mass spectrometry and NMR spectroscopic methods. Antimicrobial acti vity was estimated against Candida albicans and Gram-positive bacteria including Mycobacterium spp.