LONG-LASTING EFFECT OF TRAINING ON INSULIN RESPONSIVENESS IN THE RAT

In vivo insulin sensitivity and responsive ness were assessed in rats one day (Day 1), seven days (Day 7), and 3 weeks (Day 21) after cessat ion of training, using a 2-stage sequential hyperinsulinemic euglycemi c clamp technique (insulin infusion rate: 4.4 mU . kg(-1) . min(-1) an d 26.4 mU . kg(-1) . min(-1)). The day after the last bout of exercise , the glucose infusion rate (GIR-L: 4.4 mU-dose), which is an index of insulin sensitivity, was significantly higher in the trained group (1 1.5 +/- 1.1 mg . kg(-1) . min(-1)) than in the control group (6.1 +/- 0.6 mg . kg(-1) . min(-1) p<0.01). Detraining decreased GIR-L signific antly, to 7.4 +/- 0.5 (Day 7: p < 0.01) and 7.4 +/- 0.5 mg . kg(-1) . min(-1) (Day 21: p < 0.05). Insulin responsiveness, assessed by respon se to a 26.4 mU-dose of insulin (GIR-H), was also increased by trainin g, from 21.8 +/- 1.2 mg . kg(-1) . min(-1) (control) to 32.9 +/- 1.2 ( Day 1, p < 0.01). Seven days after cessation of training period the le vel was nearly identical (33.4 +/- 1.0 mg . kg(-1) . min(-1)) and rema ined high 3 weeks after training (30.8 +/- 1.0: p < 0.01, vs control). These data indicate that insulin responsiveness remains elevated for 3 weeks after training, although insulin sensitivity is reversed withi n seven days. These results may be attributed to changes in body compo sition or long-lasting changes in post-receptor mechanisms.