SHORT-ROUTE SYNTHESIS OF A GLYCEROPHOSPHOLIPID BEARING AN UNSATURATEDACYL GROUP AT THE SN-1 POSITION

Authors
BABA N AKIYAMA T TAHARA S NAKAJIMA S
Citation
N. Baba et al., SHORT-ROUTE SYNTHESIS OF A GLYCEROPHOSPHOLIPID BEARING AN UNSATURATEDACYL GROUP AT THE SN-1 POSITION, Bioscience, biotechnology, and biochemistry, 59(2), 1995, pp. 353-354
Citations number
8
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
59
Issue
2
Year of publication
1995
Pages
353 - 354
Database
ISI
SICI code
0916-8451(1995)59:2<353:SSOAGB>2.0.ZU;2-V
Abstract
A short-route synthesis of an optically active phosphocholine bearing an unsaturated acyl group at the sn-1 position was developed via lipas e-catalyzed enantioselective acylation of 2-O-methoxyethoxymethylglyce rol, removal of the MEM group by employing catechol boron bromide, sub sequent DCC-mediated acylation of the hydroxy group at the 2-position and final introduction of a choline phasphate moiety.