OBJECTIVE: To determine whether older age is associated with a decreas
e in self-reported depressive symptoms, independent of examiner-rated
symptoms, in inpatients with major depression. DESIGN: Survey study. S
ETTING: Inpatient psychiatric units at a university medical center. PA
TIENTS: Eligible subjects were those over 20 years of age with a prima
ry diagnosis of DSM-III-R major depression. Participation was sought f
rom all subjects over 60 years of age and from every second or every t
hird younger subject, depending on rater availability. Of 137 eligible
subjects, 97 completed all study measures. MEASUREMENTS: The Beck Dep
ression Inventory (BDI), as a measure of self-reported depressive symp
toms, was the dependent variable. The Hamilton Rating Scale for Depres
sion (Ham-D) was used to assess examiner-rated symptoms. MAIN RESULTS:
Older age (P = .03) was associated negatively and examiner-rated depr
essive symptoms (P = .0001) were associated positively with BDI score.
Other variables, including gender, education, age of depression onset
, and medical illness burden, were not independently associated with B
DI. Examination of depressive symptom subtotals (psychologic/affective
vs. somatic/neurovegetative) revealed that only the self-reported psy
chologic/affective subtotal was significantly associated with age (P =
.0018). CONCLUSIONS: Some older patients with clinically significant
depression underreport their symptoms. When asking older patients abou
t depressive symptoms, clinicians should view negative responses only
within larger clinical contexts and should obtain information from oth
er sources as needed. Similar concerns must temper interpretation of r
esearch that relies on subject self-report to study depression in late
life.