THE ROLE OF DECREASED RETINOBLASTOMA PROTEIN EXPRESSION IN ACUTE MYELOMONOCYTIC AND MONOBLASTIC LEUKEMIAS

The results of different investigators show that lack of p105 expressi on is relatively common in human myeloid leukemias, especially in mono cytic leukemias. This suggests that loss of p105 expression could cont ribute to the altered growth control of these cells. So far no clear d ata exist which show that low p105 levels in AML blasts predict a poor therapy outcome. Therefore it is not very likely that p105 expression will become a strong prognostic factor for the different treatment st rategies in AML.