The German Hypertension League comments on the efficacy and safety pro
file, especially the risk/benefit ratio of ACE-inhibitors (ACEI). It i
s pointed out that ACEI are effective in lowering blood pressure witho
ut tolerance development in long-term treatment. They are generally we
ll tolerated. Possible adverse effects including persistent cough, hyp
otension, renal impairment, hyperkalemia and, rarely, angiooedema are
critically discussed. Potential useful effects with regard to cardiova
scular or renal complications are presented.