CHANGED INTERFERON STATUS OF PATIENTS WIT H ACUTE VIRAL-HEPATITIS-B AFTER INTRAMUSCULAR AND RECTAL ADMINISTRATION OF GENE-ENGINEERING ALPHA(2)-INTERFERON

Viferon(500) suppositoria representing a combination of recombinant al pha(2)-interferon and membrane-stabilizing agents were used in the tre atment of adult patients with acute viral hepatitis B. Changes in inte rferon status of the blood under the effect of reaferon and viferon(50 0) were studied. Both reaferon and viferon(500) suppositoria were foun d to stimulate interferonogenesis in patients with acute viral hepatit is B, their stimulating effect correlating with the positive time cour se of clinical manifestations of the disease. The results permit us re commend viferon(500) for the treatment of viral hepatitis in the early period of the icterus in order to prevent the disease progress. Param eters of the interferon system may serve as an objective criterion for assessment of the treatment efficacy.