F. Leborgne et al., BREAST-CONSERVATION TREATMENT OF EARLY-STAGE BREAST-CANCER - PATTERNSOF FAILURE, International journal of radiation oncology, biology, physics, 31(4), 1995, pp. 765-775
Citations number
41
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: This study retrospectively assesses the patterns of failure i
n conservatively treated early stage breast cancer patients by correla
ting various clinical, pathologic, and treatment-related factors with
local, axillary, and distant relapse. Methods and Materials: Between 1
973 and 1990, 796 patients (817 breasts) received breast conservation
surgery followed by radiotherapy. Local recurrences were counted as ev
ents even if they occurred simultaneously or after the appearance of a
xillary or distant metastases. Results: The 10-year actuarial relative
disease-free survival (DFS) rate for T1N0, T2N0, and T1-2N1 was 82%,
71%, and 54%, respectively. Stage N0 patients had a significant DFS ad
vantage over N1 patients (p = 0.02). The 15-year actuarial local recur
rence-free rate for T1 and n tumors was 82% and 87%, respectively (p =
nonsignificant). Univariate analysis identified three significant ris
k factors for local relapse: (a) 48 breasts with tumors showing an ext
ensive intraductal component had a crude local recurrence rate of 23%
compared to 8% for 769 breasts without intraductal component (p = 0.00
16); (b) the actuarial 10-year local recurrence-free rate for patients
under age 40 years was 64% compared to 88% for patients over 40 years
(p < 0.0001); (c) the 10-year actuarial local recurrence-free rate fo
r 416 postmenopausal women without adjuvant tamoxifen was 83% compared
to 97% for 107 postmenopausal women with tamoxifen (p = 0.0479). Salv
age therapy for operable local recurrent patients resulted in a 8-year
actuarial DFS rate of 47%, significantly lower than that obtained wit
h primary treatment. The incidence of axillary relapse as the first si
gn of recurrence was 2%, and could be correlated with the lack of axil
lary dissection (p < 0.0000005) and primary tumor size (p = 0.03), Rad
iotherapy to the axilla did not influence axillary relapse. Actuarial
5-year DFS rate after treatment of isolated axillary recurrence was 27
%. Axillary failure was a marker for distant failure. Contralateral br
east cancer occurred in 8% of patients and did not have a detrimental
effect on survival. Adjuvant tamoxifen decreased the 9-year actuarial
incidence of contralateral breast cancer from 10% to 4% (p = 0.053). C
onclusions: Tumors with extensive intraductal component, age under 40
years, and the omission of adjuvant tamoxifen in postmenopausal women
increased local recurrence rate. Stage T2 and the lack of axillary dis
section increased axillary recurrence rate. Stage N+ and local or axil
lary relapse increased distant failure rate. Axillary irradiation did
not influence locoregional control nor survival. Improved therapy is n
eeded for relapsing patients.