MATRIX SWELLING - A SIMPLE-MODEL DESCRIBING EXTENT OF SWELLING OF HPMC MATRICES

Authors
WAN LSC HENG PWS WONG LF
Citation
Lsc. Wan et al., MATRIX SWELLING - A SIMPLE-MODEL DESCRIBING EXTENT OF SWELLING OF HPMC MATRICES, International journal of pharmaceutics, 116(2), 1995, pp. 159-168
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
116
Issue
2
Year of publication
1995
Pages
159 - 168
Database
ISI
SICI code
0378-5173(1995)116:2<159:MS-ASD>2.0.ZU;2-O
Abstract
The swelling of HPMC matrices was measured by determining the vertical displacement with time using a dial indicator. Curve fitting of the d ata of swelling was carried out by using the coupled Case I-Case II mo del. The thickness of the swollen layer formed around the matrix core was greater in HPMC compacts of higher viscosity grade. The rates of C ase I (alpha(s) coefficient) and Case II (beta(s) coefficient) swellin g mechanisms increased with concentration and/or viscosity grade of HP MC.