ORAL BIOAVAILABILITY OF VANCOMYCIN SOLID-STATE EMULSIONS

Authors
SHIVELY ML THOMPSON DC
Citation
Ml. Shively et Dc. Thompson, ORAL BIOAVAILABILITY OF VANCOMYCIN SOLID-STATE EMULSIONS, International journal of pharmaceutics, 117(1), 1995, pp. 119-122
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
117
Issue
1
Year of publication
1995
Pages
119 - 122
Database
ISI
SICI code
0378-5173(1995)117:1<119:OBOVSE>2.0.ZU;2-V
Abstract
Vancomycin was incorporated within water-in-oil-in-water (w/o/w) emuls ions prepared from solid-state emulsions. Vancomycin, which is not nor mally orally absorbed, was significantly absorbed, i.e., 30% +/- 0.56 (SE) after 36 h in rats (N = 3). The vancomycin concentration-time pro file indicated that sustained release of vancomycin was very reproduci ble. Vancomycin was detected in serum by fluorescence polarization imm unoassay (TDx, Abbott).