A CASE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS WITH ANTIINSULIN ANTIBODY - EFFECT OF SUBCUTANEOUS INJECTION OF HUMAN RECOMBINANT INSULIN-LIKE GROWTH-FACTOR-I

We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NID DM) patient with antiinsulin antibody, in whom insulin-like growth fac tor-I (IGF-I) was shown to be effective as a blood glucose-lowering ag ent. Due to the presence of the antibody, the patient suffered from po stprandial hyperglycemia and frequent hypoglycemia, which were uncontr ollable even by multiple insulin injection therapy. In contrast to ins ulin injection (0.24 IU/kg body wt) which showed a delayed glucose-low ering effect, subcutaneous injection of recombinant human IGF-I (0.05- 0.1 mg/kg body wt) caused a quick fall in plasma glucose levels. Prolo ngation of the glucose-lowering effect of ''rapid-acting'' insulin fre quently caused subsequent hypoglycemia in this patient, but the effect of IGF-I seemed to have disappeared within the first three hours.