A CASE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS WITH ANTIINSULIN ANTIBODY - EFFECT OF SUBCUTANEOUS INJECTION OF HUMAN RECOMBINANT INSULIN-LIKE GROWTH-FACTOR-I
Y. Kajimoto et al., A CASE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS WITH ANTIINSULIN ANTIBODY - EFFECT OF SUBCUTANEOUS INJECTION OF HUMAN RECOMBINANT INSULIN-LIKE GROWTH-FACTOR-I, Endocrine journal, 42(1), 1995, pp. 101-105
We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NID
DM) patient with antiinsulin antibody, in whom insulin-like growth fac
tor-I (IGF-I) was shown to be effective as a blood glucose-lowering ag
ent. Due to the presence of the antibody, the patient suffered from po
stprandial hyperglycemia and frequent hypoglycemia, which were uncontr
ollable even by multiple insulin injection therapy. In contrast to ins
ulin injection (0.24 IU/kg body wt) which showed a delayed glucose-low
ering effect, subcutaneous injection of recombinant human IGF-I (0.05-
0.1 mg/kg body wt) caused a quick fall in plasma glucose levels. Prolo
ngation of the glucose-lowering effect of ''rapid-acting'' insulin fre
quently caused subsequent hypoglycemia in this patient, but the effect
of IGF-I seemed to have disappeared within the first three hours.