SENSITIVITY OF TUMOR-CELLS TO LOW-DOSES O F ANTICANCER DRUGS

The anticancer activity of water solutions of nitrosomethylurea, adrib lastin and cisplatin at low and extra low concentrations (to 10(-15) M ) was studied in the mice with experimentally induced tumor. Single an d multiple administration of these drugs at extra low doses changed th e life duration. Nitrosomethylurea (10(-15) M) increased the life dura tion by 20-86%. Nitrosomethylurea at extra low concentrations modifies the organism and tumor sensitivity to subsequent action of a high dos e of this drug.