Tv. Krutova et al., SENSITIVITY OF TUMOR-CELLS TO LOW-DOSES O F ANTICANCER DRUGS, Izvestia Akademii nauk SSSR. Seria biologiceskaa, (5), 1994, pp. 738-744
The anticancer activity of water solutions of nitrosomethylurea, adrib
lastin and cisplatin at low and extra low concentrations (to 10(-15) M
) was studied in the mice with experimentally induced tumor. Single an
d multiple administration of these drugs at extra low doses changed th
e life duration. Nitrosomethylurea (10(-15) M) increased the life dura
tion by 20-86%. Nitrosomethylurea at extra low concentrations modifies
the organism and tumor sensitivity to subsequent action of a high dos
e of this drug.