ENANTIOSELECTIVE IODOCARBOCYCLIZATION OF 4-ALKENYLMALONATE DERIVATIVES USING A CHIRAL TITANIUM COMPLEX

Authors
INOUE T KITAGAWA O KURUMIZAWA S OCHIAI O TAGUCHI T
Citation
T. Inoue et al., ENANTIOSELECTIVE IODOCARBOCYCLIZATION OF 4-ALKENYLMALONATE DERIVATIVES USING A CHIRAL TITANIUM COMPLEX, Tetrahedron letters, 36(9), 1995, pp. 1479-1482
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
9
Year of publication
1995
Pages
1479 - 1482
Database
ISI
SICI code
0040-4039(1995)36:9<1479:EIO4D>2.0.ZU;2-R
Abstract
The iodocarbocyclization of 4-pentenylmalonate derivatives 1 proceeded with moderate to high enantiomeric excesses (up to 85 %ee) by treatin g 1 with I-2 and CuO in the presence of the chiral titanium alkoxide 2 . The present reaction should serve as a new method for enantioselecti ve construction of functionalized cyclopentane derivatives.