Xf. Shi et al., REACTIONS OF BETA-FLUOROVINAMIDINIUM SALT WITH BIFUNCTIONAL HETERO NUCLEOPHILES - A NEW SYNTHETIC ROUTE TO FLUORINATED HETEROCYCLES, Tetrahedron letters, 36(9), 1995, pp. 1527-1530
beta-Fluorovinamidinium salt (2), readily prepared from N-(2,3,3-trifl
uoro-1-propenyl)trimethylammonium iodide (1) and diethylamine, reacted
with bifunctional hetero nucleophiles such as amidine and guanidine h
ydrochlorides in the presence of a base to afford regiospecifically mo
nofluorinated pyrimidines 4 in good yields. The one-pot procedure star
ting from 1 was applicable for synthesizing heterocyclic compounds 4 i
n almost comparable yields.