KUEHNEROMYCIN-A AND KUEHNEROMYCIN-B, 2 NEW BIOLOGICAL ACTIVE COMPOUNDS FROM A TASMANIAN KUEHNEROMYCES SP (STROPHARIACEAE, BASIDIOMYCETES)

In a search for new inhibitors of RNA-directed DNA-polymerases kuehner omycin A (1) was isolated from fermentations of a Tasmanian Kuehneromy ces species. Its structure was elucidated by spectroscopic methods. Ku ehneromycin A (1) is a non-competitive inhibitor of avian myeloblastos is virus (K-i 200 mu M) and moloney murine leukemia virus (K-i 40 mu M ) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different i nducers. In addition, both compounds exhibit cytotoxic and antimicrobi al activities.