STUDIES ON ACTIVATION OF H-3 HISTAMINE-RECEPTOR - A MECHANISTIC MODEL

Authors
KARPINSKA G MAZUREK AP
Citation
G. Karpinska et Ap. Mazurek, STUDIES ON ACTIVATION OF H-3 HISTAMINE-RECEPTOR - A MECHANISTIC MODEL, Zeitschrift fur Naturforschung. C, A journal of biosciences, 50(1-2), 1995, pp. 143-147
Citations number
18
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
50
Issue
1-2
Year of publication
1995
Pages
143 - 147
Database
ISI
SICI code
0939-5075(1995)50:1-2<143:SOAOHH>2.0.ZU;2-4
Abstract
The recognition and the activation mechanism of the H-3 histamine rece ptor was studied based on quantum-chemical calculations. A mechanistic model proposed both for recognition and activation stage clarifies di fferent properties of histamine and alpha-methylhistamine at the H-3 r eceptor. Interaction with a hypothetical receptor sites leads to the o pening of the intramolecular hydrogen bonding in histamine, whereas th e alpha-methylhistamine remains in closed conformation.