ANTIVIRAL ACTIVITY OF S-7HNA ON THE INFECTIVITY AND REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN CULTURED-CELLS

Authors
MURATORE O SCHITO AP TONOLI EL MOSTI L
Citation
O. Muratore et al., ANTIVIRAL ACTIVITY OF S-7HNA ON THE INFECTIVITY AND REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN CULTURED-CELLS, Journal of chemotherapy, 7(1), 1995, pp. 30-32
Citations number
NO
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Journal of chemotherapy → ACNP
ISSN journal
1120009X
Volume
7
Issue
1
Year of publication
1995
Pages
30 - 32
Database
ISI
SICI code
1120-009X(1995)7:1<30:AAOSOT>2.0.ZU;2-L
Abstract
The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HN a) on the infectivity and replication of herpes simplex virus type 1 i n Vero cultured cells was studied. S-7HNa, at the highest concentratio n lacking cytotoxicity (10 mM), produced, at various inocula, a 70% in hibition of HSV-1 infectivity with respect to the plaque formation det ected in control infected cultures. This inhibitory activity was subst antiated by studies on progeny production, S-7HNa revealed a therapeut ic index higher than that of the correlative ester (S-7).