EVALUATION OF THE EFFECTS OF PEFLOXACIN ON PLATELET-AGGREGATION IN-VITRO AND EX-VIVO IN PATIENTS SUFFERING FROM CHRONIC-BRONCHITIS

The effects of pefloxacin on adenosine- diphosphate (ADP) and collagen -induced human platelet aggregation in vitro and ex vivo in patients s uffering from chronic bronchitis were investigated. In the in vitro st udy carried out on platelets from 12 healthy volunteers, pefloxacin ha d no effect on platelet function even at a concentration of 10 mg/ml, which is 1,500 times higher than that reached in vivo. In the ex vivo study carried out in 10 patients, who received pefloxacin twice daily for 7-10 days as 400 mg oral dose, the drug did not influence platelet aggregation up to 24 hows after administration of the last oral dose.