TREATMENT OF EXTERNAL ANOGENITAL CONDYLOM A WITH 0,5 PER CENT PODOPHYLLOTOXIN

There are several possible protocols for the treatment of ano-genital condylomata. In this study, the efficacy of podophyllotoxin (0.5%) was asseded. The authors observed a recovery rate at 1 month of 81% in ca ses of condylomata of the balano-preputial and vulvar mucous membranes , a rate of 67% in condylomata of the keratinised tissues and 63% in t hose of the anal margin. Response to treatment is also dependent on th e morphology of the lesion; regression was observed in 78% of cases of condylomata acuminata and in 57% of cases of endophytic condylomata. The side effects were local and consisted of erosion in 20% of cases. The efficacy of treatment was, amongst other things, analysed accordin g to the recurrence of the infection at one month, which occurred in 1 6% of cases affecting mucous membranes. In the therapeutic arsenal for the treatment of condylomata, podophyllotoxin 0.5% is a first line tr eatment for condylomata acuminata of the genital mucous membranes.