CHROMOSOMAL LOCALIZATION OF THE GAMMA-GLUTAMYL CARBOXYLASE GENE AT 2P12

We have used two complementary approaches to analyze the chromosomal l ocation of the gamma-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (P CR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned t he gene to p12 of chromosome 2. Our results indicate that the gamma-gl utamyl carboxylase gene has a single locus in the human genome. (C) 19 95 Academic Press, Inc.