STIMULATION OF VGF GENE-EXPRESSION BY NGF IS MEDIATED THROUGH MULTIPLE SIGNAL-TRANSDUCTION PATHWAYS INVOLVING PROTEIN-PHOSPHORYLATION

Citation
Srj. Salton et al., STIMULATION OF VGF GENE-EXPRESSION BY NGF IS MEDIATED THROUGH MULTIPLE SIGNAL-TRANSDUCTION PATHWAYS INVOLVING PROTEIN-PHOSPHORYLATION, FEBS letters, 360(2), 1995, pp. 106-110
Citations number
43
Categorie Soggetti
Biophysics,Biology
Journal title
ISSN journal
00145793
Volume
360
Issue
2
Year of publication
1995
Pages
106 - 110
Database
ISI
SICI code
0014-5793(1995)360:2<106:SOVGBN>2.0.ZU;2-G
Abstract
The vgf gene encodes one of the most rapidly induced neuronal mRNAs id entified in NGF-treated PC12 cells, Maximal inhibition of VGF mRNA ind uction was achieved using K-252a, an inhibitor of the NGF-receptor Trk tyrosine kinase, and by mutating both Y490 (SHC association site) and Y785 (PLC-gamma l association site) of Trk. Inhibitors of the NGF-act ivated protein kinase N (PKN) were found to partially and in some case s transiently block VGF induction by NGF while in PKA-deficient PC12 c ells, VGF induction by NGF was comparable to that observed in parental PC12 cells, The binding of NGF to Trk therefore activates redundant s ignal transduction pathways which converge to regulate vgf gene expres sion,