THE ANALYSIS OF MODIFIED PEROXISOME PROLIFERATOR RESPONSIVE ELEMENTS OF THE PEROXISOMAL BIFUNCTIONAL ENZYME IN TRANSFECTED HEPG2 CELLS REVEALS 2 REGULATORY MOTIFS

Authors
BARDOT O CLEMENCET MC PASSILLY P LATRUFFE N
Citation
O. Bardot et al., THE ANALYSIS OF MODIFIED PEROXISOME PROLIFERATOR RESPONSIVE ELEMENTS OF THE PEROXISOMAL BIFUNCTIONAL ENZYME IN TRANSFECTED HEPG2 CELLS REVEALS 2 REGULATORY MOTIFS, FEBS letters, 360(2), 1995, pp. 183-186
Citations number
18
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
360
Issue
2
Year of publication
1995
Pages
183 - 186
Database
ISI
SICI code
0014-5793(1995)360:2<183:TAOMPP>2.0.ZU;2-5
Abstract
Peroxisome proliferators (PPs) are non-genotoxic carcinogens in rodent s, They can induce the expression of numerous genes via the heterodime rization of two members of the steroid hormone receptor superfamily, c alled the peroxisome proliferator-activated receptor (PPAR) and the 9- cis retinoic acid receptor (RXR). Many of the PP responsive genes poss ess a peroxisome proliferator response element (PPRE) formed by two TG ACCT-related motifs. The bifunctional enzyme (HD) PPRE contains 3 such motifs, creating DR1 and DR2 sequences. PPAR and RXR regulate transcr iption via the DR1 element while DR2 modulates the expression of the g ene via auxiliary factors in HepG2 cells.