MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF THE GUINEA-PIG CARDIACNA-CA2+ EXCHANGER()

Authors
TSURUYA Y BERSOHN MM LI ZP NICOLL DA PHILIPSON KD
Citation
Y. Tsuruya et al., MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF THE GUINEA-PIG CARDIACNA-CA2+ EXCHANGER(), Biochimica et biophysica acta. Biomembranes, 1196(1), 1994, pp. 97-99
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1196
Issue
1
Year of publication
1994
Pages
97 - 99
Database
ISI
SICI code
0005-2736(1994)1196:1<97:MAFEOT>2.0.ZU;2-G
Abstract
The cDNA of the guinea pig cardiac Na+-Ca2+ exchanger was cloned from a lambda ZAP cDNA library. The deduced sequence of the protein corresp onds to 970 amino acids and is 98% identical to the canine cardiac exc hanger. The leader peptide region shows substantial variation among sp ecies. The cloned cDNA can induce Na+-Ca2+ exchange activity when in v itro transcribed cRNA is injected into Xenopus laevis oocytes.