CILIARY NEUROTROPHIC FACTOR (CNTF) INDUCES SERUM AMYLOID-A, HYPOGLYCEMIA AND ANOREXIA, AND POTENTIATES IL-1 INDUCED CORTICOSTERONE AND IL-6PRODUCTION IN MICE
G. Fantuzzi et al., CILIARY NEUROTROPHIC FACTOR (CNTF) INDUCES SERUM AMYLOID-A, HYPOGLYCEMIA AND ANOREXIA, AND POTENTIATES IL-1 INDUCED CORTICOSTERONE AND IL-6PRODUCTION IN MICE, Cytokine, 7(2), 1995, pp. 150-156
Ciliary neurotrophic factor (CNTF) supports the survival of ciliary ga
nglion neurons and was shown to induce the synthesis of acute-phase pr
oteins and fever, We studied the effect of CNTF, alone or in associati
on with IL-1, on levels of corticosterone (CS), glucose, serum amyloid
A (SAA), and IL-6, We also compared the effect of CNTF with that of I
L-6, since the gp130 receptor subunit for CNTF is shared with that of
IL-6, A single intravenous injection of CNTF induced hypoglycaemia and
SAA and potentiated IL-1-induced CS and IL-6, Chronic CNTF, but not I
L-6, resulted in decreased food intake and body weight up to days 6-7,
After this time, body weight and food intake recovered even if CNTF t
reatment was continued, indicating that a phenomenon of tolerance occu
rred, Finally, CNTF (unlike IL-1) was not toxic in adrenalectomized mi
ce, Therefore the similarities of CNTF activities with those of other
cytokines, particularly IL-6, might go beyond the activation of the sa
me receptor-signal transduction pathway of IL-6.