HEPATIC GAMMA-GLUTAMYL CYSTEINE SYNTHETASE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITIES IN GALACTOSAMINE TREATED RATS

Authors
SECKIN S ALPTEKIN N KOCAKTOKER N UYSAL M AYKACTOKER G
Citation
S. Seckin et al., HEPATIC GAMMA-GLUTAMYL CYSTEINE SYNTHETASE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITIES IN GALACTOSAMINE TREATED RATS, Research communications in molecular pathology and pharmacology, 87(2), 1995, pp. 237-240
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
87
Issue
2
Year of publication
1995
Pages
237 - 240
Database
ISI
SICI code
1078-0297(1995)87:2<237:HGCSAG>2.0.ZU;2-8
Abstract
Liver homogenate glutathione (GSH) content, lipid peroxide levels and the activities of GSH metabolizing enzymes were studied in rats after 24 hours of galactosamine (GalN) treatment. Lipid peroxide levels incr eased whereas hepatic GSH content was decreased significantly. On the other hand, hepatic gamma-glutamyl cysteine synthetase activity was un affected by GalN administration but gamma-glutamyl transpeptidase acti vity increased.