M. Ogan et al., PREPARATION OF [I-125] 3H2-LOPIPERIDOL-A BY EXCHANGE RADIOIODINATION, Journal of labelled compounds & radiopharmaceuticals, 36(3), 1995, pp. 235-242
Preparation of radiolabeled peridinyl)-2,4,6-triiodo-1,3-benzenedicarb
oxamide, ([I-125]-3H(2-iopiperidol-A), a nonionic radiographic contras
t agent, was achieved by HAuCl4 mediated exchange radioiodination. [I-
125]-lopiperidol-A was isolated by reversed-phase HPLC in 83% radioche
mical yield. The radiochemical purity of isolated [I-125]-3H2-iopiperi
dol-A was 98.7% and the specific activity was 6.6 mCi/mu mol. The role
of HAuCl4 in facilitating exchange radioiodination of 3H2-iopiperidol
-A, however, appears to be a complex process not limited to the produc
tion of electrophilic iodine ion.