Laser light has unique properties that enable transmission of high amo
unts of energy to a narrowly defined site. Biological effects may be t
hermal, chemical, or mechanical. Medical procedures involve mainly the
rmal tissue destruction by coagulation (>60 degrees C) or ablation (>3
00 degrees C). The effect is governed by tissue optical and thermal pr
operties and laser variables; contact/non-contact, focus, output power
(W), and exposure rime (s). The laser medium governs the wavelength e
mitted. The carbon dioxide (CO2) laser light (10600 nm) requires trans
mission through articulating arms with mirrors, whereas neodymium:yttr
ium-aluminum-garnet (Nd:YAG) (1064 nm), and argon (488/515 nm) light c
an be transmitted through flexible quartz fibres. CO2 lasers are used
mainly for high precision tissue ablation; Nd:YAG lasers can coagulate
or vaporise larger tissue areas and argon laser applications involve
vascular destruction, based on selective absorption by haemoglobin. Re
search has shifted towards a fundamental understanding of the interact
ions of light with biological tissue, to allow treatment planning and
to optimise laser procedures. Applications such as interstitial laser
coagulation fur local destruction of solid rumours deserve further exp
loration in general surgery.