COMPLEXATION OF GLUCOSE BY ALPHA-CYCLODEXTRINS AND BETA-CYCLODEXTRINS

The concentration of glucose in aqueous solutions was monitored, using a blood glucose meter, as small weighed cyclodextrin portions were ad ded, Equilibrium constants for the formation of inclusion complexes we re calculated. A binding constant determined by this method has been v erified by a technique involving competition of the guest with methyl orange indicator dye. Delta H-0 values for the reactions were estimate d using calorimetry. These values along with Delta G(0) provided estim ates of the standard entropies. The values calculated compare favorabl y with those from a previously determined empirical equation. The poss ibility of hydrogen bond formation is suggested by the large negative enthalpies as well as by molecular mechanics calculations.