INVESTIGATION OF 123 CHIRAL DRUGS BY CYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS

Authors
LIN BC ZHU XF KOPPENHOEFER B EPPERLEIN U
Citation
Bc. Lin et al., INVESTIGATION OF 123 CHIRAL DRUGS BY CYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS, LC GC, 15(1), 1997, pp. 40
Citations number
19
Categorie Soggetti
Chemistry Analytical
Journal title
LC GC → ACNP
ISSN journal
08889090
Volume
15
Issue
1
Year of publication
1997
Database
ISI
SICI code
0888-9090(1997)15:1<40:IO1CDB>2.0.ZU;2-E
Abstract
The authors investigated 123 drugs for chiral separation using seven c yclodextrins as chiral solvating additives for capillary zone electrop horesis. Of 86 detectable marketed chiral drugs, they separated 63 int o enantiomers, including all 23 drugs with tricyclic (aromatic ring nu mber) systems and 9 beta-blockler drugs. Native beta-cyclodextrin and its derivatives were promising chiral selectors compared with other cy clodextrins because of the molecule's higher degree of asymmetry.