CONSERVATIVE TREATMENT OF SUBCLINICAL, NO NINVASIVE INTRADUCTAL BREAST CARCINOMAS (102 CARCINOMAS IN-SITU, T0N0)

102 patients with sub-clinical intra ductal non invasive breast cancer (T0N0) treated by limited surgery and curative radiation therapy. Fol low-up ranged from 2 to 10 years with a median follow-up of 59 months. The long term survival rate of this therapeutic approach, consisting of simple excision without any adjuvant treatment and radical mastecto my was close to 100 %, The actuarial local recurrence rate was only 8. 6% at 10 years (confidence interval: 4.6 to 12.6 %), which strongly su ggests that radiation therapy is active on multicentric foci. Salvage surgery could be performed in every case of local recurrence. The surv ival rate of in situ breast cancer (T0N0) treated by conservative radi o-surgery is comparable to that of radical mastectomy, while cosmetic results and psychological impact appear to be better for the conservat ive technique (breast preservation rate = 91 to 96 %).