RESPONSE TO TREATMENT, MORTALITY, AND CD4 LYMPHOCYTE COUNTS IN HIV-INFECTED PERSONS WITH TUBERCULOSIS IN ABIDJAN, COTE-DIVOIRE

We examined the severity of immune deficiency in patients with HIV-ass ociated tuberculosis in Cote d'Ivoire and assessed its effect on morta lity and response to treatment. Consecutive patients attending a tuber culosis treatment in Abidjan with smear-positive pulmonary or diagnose d extrapulmonary tuberculosis were tested for HIV-1 and HIV-2 infectio ns and had CD4 lymphocyte counts measured. Patients received standard short-course chemotherapy. Analysis of outcome (restricted to smear-po sitive tuberculosis patients) was done at 6 months. The 247 HIV-positi ve patients were significantly more likely than the 312 HIV-negative p atients to have CD4 lymphocyte counts of less than 200/mu L (43% vs 1% ; odds ratio 56.9; [95% CI 19.7-185.3]) and 200-499/mu L (39% vs 14%, odds ratio 3.8; [2.5-5.9]). HIV-positive patients, median CD4 lymphocy te in those with extrapulmonary tuberculosis (198/mu L; n=67) was lowe r, but not significantly so, than among those with pulmonary tuberculo sis (257/mu L; n=180). Among 460 patients with pulmonary tuberculosis, the overall mortality rate was significantly higher in HIV-positive t han HIV-negative persons (6% vs 0.4%; relative risk 17.1 [2.2-131.4]), and increased with the severity of immune deficiency; mortality rates in HIV-positive patients with CD4 counts of <200/mu L and 200-499/mu L were 10% and 4%, relative risk 27.6 (3.5-220.8); and 11.5 (1.2-109), respectively, compared to HIV-negatives. Among patients completing tr eatment, cure rates were similar in HIV-positive patients (93%) and HI V-negative patients (92%), and were not related to CD4 counts. Severit y of immune deficiency was the major determinant of mortality in HIV-a ssociated tuberculosis. Among people completing treatment, microbiolog ical response was satisfactory irrespective of serological or immune s tatus.