A sampling method to collect samples for Helicobacter pylori culture t
hat is easier than endoscopy would be useful. We used a capsule attach
ed to a highly absorbent nylon string, which is swallowed to obtain ga
stric secretions. Antral biopsy and string specimens, sequentially obt
ained from 36 adults with clinically suspected ulcer or gastric diseas
e were cultured. 9 (25%) patients were negative in both tests; 18 (50%
) were positive by both methods; 6 (17%) were biopsy positive and stri
ng-test negative; and 3 (8%) were biopsy negative and string-test posi
tive. The new test is useful, simple, and causes little discomfort.