WHEAT DEFICIENT IN GLIADINS - PROMISING TOOL FOR TREATMENT OF CELIAC-DISEASE

Authors
FRISONI M CORAZZA GR LAFIANDRA D DEAMBROGIO E FILIPPONI C BONVICINI F BORASIO E PORCEDDU E GASBARRINI G
Citation
M. Frisoni et al., WHEAT DEFICIENT IN GLIADINS - PROMISING TOOL FOR TREATMENT OF CELIAC-DISEASE, Gut, 36(3), 1995, pp. 375-378
Citations number
30
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Gut → ACNP
ISSN journal
00175749
Volume
36
Issue
3
Year of publication
1995
Pages
375 - 378
Database
ISI
SICI code
0017-5749(1995)36:3<375:WDIG-P>2.0.ZU;2-N
Abstract
The toxicity of two varieties of bread wheat, one poor in alpha and be ta gliadins and the other poor in alpha, beta, gamma, and omega gliadi ns, has been tested. The peptic-tryptic digest of these wheats was ass essed using coeliac mucosa in an in vitro organ culture system. A sign ificantly lower toxicity was found in respect of bread wheat containin g all gliadin fractions. These results suggest new opportunities for t he treatment of coeliac disease.