CAPTOPRIL AND ASPIRIN IN TREATMENT OF RENAL MICROANGIOPATHY IN PRIMARY ANTIPHOSPHOLIPID SYNDROME

Treatment of antiphospholipid syndrome (APS) is controversial, We repo rt a case of renal microangiopathy in a 40-year-old woman with APS, Th e nephropathy was isolated without signs of disseminated thrombotic mi croangiopathy or progressive systemic sclerosis. Similarities with scl erodermatous kidney and an increase in plasma renin activity led us to initiate treatment with aspirin and captopril, with excellent control of the renal syndrome, We believe this therapeutic regimen may be an effective means of treating the renal microangiopathy of APS. (C) 1995 by the National Kidney Foundation, Inc,